Many people ask about the quality of royal jelly and how one can determine if one supplier offers quality that is higher than the next.
The Standard for measuring royal jelly is 10-HDA content, or 10-Hydroxy-2-Decenoic Acid. This is the active substance which exists only in natural royal jelly and is often referred to as royal jelly acid. The content of 10-HDA in is usually around 1.5%-2,0%. The content of 10-HDA is the international standard of the quality of royal jelly and it directly determines the price on the international market.
As we’ve talked about elsewhere, research into the affects of bee products is quite scarce, but we offer the following reference papers which are widely available online, and if you care to you may search and read the specifics of each of the studies.
TOWNSEND, GF., MORGAN, J.F., HAZLETT, B. Activity of 10-hydroxydecenoic acid from Royal Jelly against experimental leukaemia and ascitic tumours. Nature, v. 183, n. 4670, p. 1270-1271, 1959.
Blum, Murray S.; Novak, Arthur F.; Taber, Stephen, 10-Hydroxy-2-decenoic acid, an antibiotic found in royal jelly., Science (1959), 130 452-3.
Satomi, Koya-Miyata; Okamoto, Iwao; Ushio, Shimpei; Iwaki, Kanso; Ikeda, Masao; Kurimoto, Masashi. Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Bioscience, Biotechnology, and Biochemistry (2004), 68(4), 767-773.
Miyata, Satomi; Okamoto, Iwao; Ushio, Shimpei; Kurimoto, Masashi. Collagen production enhancer and production process and use thereof. PCT mt.Appi. (2005), 34 pp.
Takimoto, Hiroyuki; Motoyoshi, Katsuhiro. Skin or hair cosmetics. Kokai Tokkyo Koho (1998), 8 pp.
Wang, Guo-Yan; Lin, Zhi-Bin. Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro. Zhongguo Yaoli Xuebao (1997), 18(2), 180-182
Yatsunami, Kazuhisa; Echigo, Takashi. Tamagawa Nogakubu Antibacterial action of royal jelly. Kenkyu Hokoku (1985), (25), 13-22.
Matsugami, Michio; Horikoshi, Haruyo; Kimura, Tomoshi; Koiso, Ichiro; Ochiai, Michio. Skin-whitening cosmetics. Kokai Tokkyo Koho (1986), 5 pp.
Karneda, Kenji; Chikaki, Mariko; Morimoto, Chie; Jiang, Ming; Okuda, Hiromichi. Insulin-like actions oftrans-10-hydroxy-2-decanoic acid and its related substances. Wakan Iyakugakii Zasshi (1996), 13(4), 456-457.
Fang, Erli; Zhou, Huazhu; Xu, Hongli; Xing, Meijuan. Antiulcer effects of 10-hydroxy-2-decenoic acid in rats. Zhongguo Yaolixue Tongbao (1994), 10(2), 13 9-42.
Xu Donghui; Mei Xueting; Xu Shibo The research of 10-hydroxy-2-decenoic acid on experiment hyperlipoidemic rat. Journal of Chinese medicinal materials (2002), 25(5), 346-7.
A summary of the various reference papers is as follows – royal jelly has many properties that may fight or inhibit the growth of tumors and cancerous cells, demonstrated in laboratory conditions on laboratory animals. Human studies into the affects of these substances have not been widely conducted and insufficient data exists with which to obtain FDA approvals for the substances in the treatment of cancers and other ailments. Learn more about the benefits here